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Prevention of Hepatitis C Virus (HCV) and HIV-1 Co-Infections

A collaborative project financed by the EC Framework Programme 7

Work Package 5 - Vaccine-induced immunity studies

Objective: To characterise the innate and adaptive immune responses elicited by prime-boost vaccinations with ChAd3 NSmut / MVA-NSmut, ChAd3 Ii-NSmut / MVA Ii-NSmut and ChAd63.HIVconsv / MVA.HIVconsv in HIV-1-positive subjects and healthy volunteers


Example Techniques:

Quick links:

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Ex-vivo IFN-γ ELISpot assay to measure the magnitude and breadth of virus-specific IFN-γ producing T cells

Investigation of CD4+ T cell help as a key determinant of responsiveness to HCV vaccines in HIV-1+ subjects using 3H-thymidine incorporation and CFSE assays

Investigation of CD8+ T cell-mediated inhibition of HIV-1 replication using flow cytometry

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